Are cyclists out to kill?

Published on linkedin.com on 2015-11-18 In Montreal these days, with later sunrises and early sunsets, many cycling commuters are going to and from work in the dark. I don’t know if this is particular to Montreal, but many of these cyclists have no lights on their bicycles, and additionally wear…

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Response to Recommendations to Increase Dietary Protein Intake During Chemotherapy

Articles supplied: Arends J, Bachmann P, Baracos V et al. ESPEN guidelines on nutrition in cancer patients. Clin Nutr. 2017;36:11-48. Stobäus N, Müller MJ, Küpferling S, Schulzke JD, Norman K. Low Recent Protein Intake Predicts Cancer-Related Fatigue and Increased Mortality in Patients with Advanced Tumor Disease Undergoing Chemotherapy. Nutr Cancer.…

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Why do mammalian males have scrota?

My hypothesis is that the scrotum, which in mammals, is often exposed, relatively hairless, and with thin skin and little subcutaneous tissue, may have evolved for perhaps a different reason than simply to provide a lower temperature for spermatogenesis. Consider that humans produce about 25,000 sperm every minute. Why so many?…

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Do PPIs suppress B12?

This letter to the Editor was published in the November 2001 issue of Parkhurst Exchange, p7 Gentlemen: In the June 2001 issure of Parkhurst Exchange, your consultant AS reported no serious side effects from the longterm use of pantoprazole, to his knowledge. Gastric acid suppressive therapy in general has been…

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Tasco Telescope 40-060578 / 40-060660 / 46-060525 Owner’s Manual / Manuel du propriétaire / Manual des usuario / Manuale dell’utente / Benutzerhandbuch / Handleiding / Manual do utilizador

PDF of the manual for three Tasco telescopes. [gview file=”http://henry.olders.ca/wordpress/wp-content/uploads/2015/12/Tasco-Telescope-40-060578-40-060660-46-060525-Owners-Manual-Manuel-du-propriétaire-Manual-des-usuario-Manuale-dellutente-Benutzerhandbuch-Handleiding-Manual-do-utilizador.pdf”]

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The role of diet in gout

Gout is caused by an excess of uric acid (urate) in the system, which can then form crystals in various places, including the joint of the big toe. Crystals in the joint cause inflammation and pain. Excess uric acid can be due to excessive dietary intake of purines, insufficient urinary…

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Methionine content of food items

To facilitate following a methionine restriction diet, I’ve put together a Filemaker solution which will provide you with the methionine content for the majority of the items in the USDA nutrients database, version SR27. The solution also includes the content of cysteine, leucine, glycine, and choline. The Predicted Renal Acid Load…

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Dealing with difficult patients

Version française General principles for dealing with difficult patients who are cognitively intact As caregivers, we often find ourselves extending ourselves for our patients, “going the extra mile”. This works well when the patient is appreciative of our efforts: we feel good about ourselves. But if our efforts are not…

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Traiter les patients difficiles

English version Principes généraux relatifs aux traitements des patients difficiles dont la fonction cognitive est intacte En tant que soignant professionnel, nous devons souvent nous dévouer “corps et âme” pour nos patients.  C’est très valorisant de savoir à quel point nos patients apprécient et qu’ils nous témoignent leur reconnaissance. Toutefois,…

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Commentary on the book “Deadly medicines and organized crime: how big pharma has corrupted healthcare” by Dr. Peter Gøtzsche

I’ve been reading a most interesting book, titled “Deadly medicines and organized crime: how big pharma has corrupted healthcare,” by Dr. Peter Gøtzsche. Dr. Gøtzsche, a specialist in internal medicine and professor at the University of Copenhagen, co-founded the Cochrane Collaboration in 1993 and established the Nordic Cochrane Centre. The…

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Senate reform in Canada

With the Mike Duffy trial figuring prominently in the news these days, The NDP is renewing calls for abolition of the Senate. Instead of outright abolition of the “House of sober second thought” perhaps a major restructuring should be considered. Here is one suggestion: Reduce the size of the senate,…

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A disappointing symposium: McConnell Brain Imaging Centre 30th Anniversary

Yesterday I attended an all-day symposium at the Montreal Neurological Institute, to celebrate the 30th anniversary of the founding of the McConnell Brain Imaging Centre. I went to hear talks by David Van Essen, Principal Investigator, The Human Connectome Project; Henry Markram, Director, The Blue Brain Project, and Coordinator, The Human Brain Project; and Robert…

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Methionine Restriction abstracts

Grandison, R. C., M. D. Piper, and L. Partridge (2009) Nature 462:1061-1064. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Dietary restriction extends healthy lifespan in diverse organisms and reduces fecundity. It is widely assumed to induce adaptive reallocation of nutrients from reproduction to somatic maintenance, aiding…

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Research Proposal: Treating Cancer-Related Anorexia-Cachexia
 with a Methionine Restricted Diet

Henry Olders, MD November 6, 2013 Research Proposal: Treating Cancer-Related Anorexia-Cachexia with a Methionine Restricted Diet Anorexia and cachexia are frequent concomitants of the later stages of cancer, and contribute significantly to poor quality of life (QOL). Moreover, family members and friends of cancer patients with anorexia and cachexia are…

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The war against Islamic State

Western democracies are lining up to engage in bombing raids against Islamic State installations, citing the IS (aka ISIS, or ISIL) terrorists as particularly cruel and barbaric, a scourge that needs to be eliminated. We’ve seen the gruesome beheadings, and heard the warnings that Canadians may become radicalized, join IS,…

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Assisted suicide

In Canada and Quebec, the debate over the right to die with dignity, medically assisted suicide, and euthanasia is often heated. I am struck by the inconsistency, perhaps even hypocrisy, of governments that maintain that it is OK for individuals to commit suicide, but not to receive help from anyone…

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Why we get old and die, and what to do about it

This presentation was most recently given at the Westmount Healthy City Project, on 2015-10-29.  It was also presented at: Institut universitaire en santé mentale Douglas Grand Rounds, 2013-5-23 Jewish General Hospital Department of Psychiatry Clinical Grand Rounds, 2012-4-12 McGill Geriatric Medicine Grand Rounds, Montreal General Hospital, 2012-1-24 Ste. Anne’s Hospital, Continuing…

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Letter to the Editor: Comment on ‘Acute Impact of Immediate Release Methylphenidate Administered Three Times a Day on Sleep in Children with Attention-Deficit/Hyperactivity Disorder’

The study reported on in the article “Acute impact of immediate release methylphenidate administered three times a day on sleep in children with attention-deficit/hyperactivity disorder” (Corkum, Panton, Ironside, Macpherson, & Williams, 2008) found a significant reduction in total sleep time of almost an hour with medication compared to the no…

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Letter to the Editor: PPIs, B12, and falls. Comment on ‘Use of proton pump inhibitors and risk of osteoporosis-related fractures’

This letter to the editor of the “Canadian Medical Association Journal” was published electronically on the CMAJ website, on 2008-11-18, in response to this article:  Targownik LE, Lix LM, Metge CJ, Prior HJ, Leung S, Leslie WD. Use of proton pump inhibitors and risk of osteoporosis-related fractures. CMAJ. 2008;179:319-326. Article…

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Depression in Long Term Care

This presentation was given on 2008-11-17 at Ste. Anne’s Hospital in the Department of Psychiatry Conference Series, and on 2008-11-20 to the Head Nurses at Ste. Anne’s Hospital. It had previously been presented to staff of CSSS Cavendish on 2008-10-8, at Centre d’Accueil Henri-Bradet. Download a pdf of the slides and…

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How to discourage gas consumption

Letter to the Editor, submitted to the Montreal Gazette on 2008-8-28. Many companies provide parking at no charge for their employees. This represents a subsidy, as parking spaces involve considerable costs including initial construction, drainage, paving, lighting as well as ongoing expenses such as snow removal, security, and electricity. Never…

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Too much, too late?

Letter to the Editor of the Montreal Gazette. It appeared in the 2006-11-24 edition under the heading “Puerile bullyboy”. Dan McTeague criticises Prime Minister Harper (letters, 23 Nov 2006) for “openly” chastising China on its human-rights record and bringing up the case of Huseyin Celil, then complains that he should…

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Does a fish a day keep the doctor away? The role of omega-3 fatty acids in psychiatry

This presentation was given on 2006-9-5 at Ste. Anne’s Hospital, Ste-Anne-de-Bellevue, Québec. Earlier versions of this talk were presented at: • Consultation-Liaison Psychiatry Rounds, Sir Mortimer B. Davis – Jewish General Hospital, 2002-6-28 • Department of Psychiatry Clinical Grand Rounds, Sir Mortimer B. Davis – Jewish General Hospital, 2002-9-12 •…

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Does too much sleep cause depression?

Presented at Ste. Anne’s Hospital 2006-5-9 and on 2006-6-1. Some proverbs about sleep: “One hour’s sleep before midnight is worth two hours after.”
—John Rays (1627-1705): A Compleat Collection of English Proverbs, 1670 “Plough deep while sluggards sleep.”
—Benjamin franklin (1706-1790): Maxim prefixed to Poor Richard’s Almanac, 1757 “The early bird catches…

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“Sleeper cells”

Letter to the Editor of the Montreal Gazette. It appeared in the 2006-3-8 edition under the heading “Lack of vitamin B12 also causes lesions”. The article “Brain’s ‘sleeper cells’ stalking boomers” (7 mar 2006) points out that white matter lesions in the brain predict stroke and dementia. It fails to…

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hammingNN progress report

Since my medical school days, I’ve been mulling over some ideas for artificial neural networks that adhere more closely to the physiology that I studied. Over the past couple of years, I finally implemented those ideas, using the Forth programming language on a Macintosh. The process went considerably faster than…

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Ritalin (methylphenidate)

Ritalin • -more effective than sertraline in improving cognitive function and maintaining alertness in patients with traumatic brain injury (Lee H 20 p97) • better tolerated than sertraline (ibid.) • -found effective in hypoactive delirium, apathy, depressive syndrome (Meyers BJ 148 1738) • -accelerates antidepressant response in elderly (Lavretsky H…

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Journal club: olfactory perception, communication, and the nose-to-brain pathway

Consultation-Liaison Rounds, 05-3-3, at the SMBD – Jewish General Hospital Article: Stockhorst, U., and R. Pietrowsky (2004) Physiol Behav 83:3-11. Olfactory perception, communication, and the nose-to-brain pathway. Abstract: The present paper’s aim is of to give an overview about the basic knowledge as well as actual topics of olfaction–with a…

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Same-sex marriage

Letter to the Editor of the Montreal Gazette. An edited version appeared in the 2005-1-27 edition under the heading “It’s up to the PM to convince us”. It appears that once again the federal government is attempting to pull the wool over the eyes of Canadians. Prime Minister Paul Martin…

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Referendum on same-sex marriage

Letter to the Editor of the Montreal Gazette, It appeared in the 2004-12-15 edition under the heading “Referendum way to express opinion”. Your editorial (”Vote no on this”, Gazette 2004-12-14) decries referendums as divisive, and blames them for creating or widening wounds in the fabric of Canadian society. In reality,…

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Proposed ban of trans fats

Letter to the Editor of the Montreal Gazette. One would think we had learned nothing from the U.S. experience with Prohibition, or the War on Drugs. Banning a substance such as alcohol or marijuana inevitably leads to the creation of a criminal underground which profits enormously, and supports a large…

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Sanctuary in churches

Letter to the Editor of the Montreal Gazette. Immigration Minister Judy Sgro believes that it is inappropriate for churches and other faith communities to provide sanctuary to refugee claimants who have been ordered deported after their hearings. It has been argued that churches should not usurp the role of democratically…

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Suspended with pay

An edited version of this letter to the editor of the Montreal Gazette appeared in the 2004-8-2 edition under the heading “Suspension with pay not a bad idea”. Given the demonstrated inability of many government or crown corporation bureaucrats to do their jobs properly, it seems pretty clear that they…

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Tremblay’s outrage

An edited version of this letter to the editor of the Montreal Gazette appeared in the 2004-6-18 edition under the heading “Lavish lunches exemplify abuses”. So Mayor Tremblay is outraged that members of his political party were reimbursed for lunches and vintage wines out of our taxes? Nothing to compare…

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Election posters up prematurely

Letter to the Editor of the Montreal Gazette. The federal liberals have made flouting the rules an art form, as demonstrated by the sponsorship scandal, Radwanski’s expense accounts, and the Shawinigate affair. Now, in Westmount, liberal incumbent Lucienne Robillard’s overeager campaign team are breaking the rules by erecting election posters…

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Why megacities?

Letter to the Editor of the Montreal Gazette. The various arguments that have been made in favour of merging smaller municipalities into megacities have been demolished, one by one, as these undemocratically created monstrosities (monstrocities?) have failed to produce promised reductions in costs. It seems that the only remaining rationale…

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School board elections

Letter to the Editor of the Montreal Gazette. The recent school board elections were noteworthy for the low voter turnout, and for the mysterious process whereby some voters who previously had been on the English school board electoral lists saw their names turn up on the lists for francophone school…

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Transit strike

Letter to the Editor of the Montreal Gazette. The strike of MTC maintenance workers is a terrible hardship for many people, but is it really necessary to limit service to a few hours daily and none on weekends? After all, it isn’t the bus drivers who are striking; it’s the…

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What causes insomnia?

This article was published on the website of Scientific American, on 2003-5-12. download a pdf file of the web article. An edited version appeared in the print edition of Scientific American, October 2003. Download a pdf file of the print article. The articles were republished in 2006 in the print and online…

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Assessment of depression in dementia

This was presented on 2003-9-19 at the McGill Division of Geriatric Medicine First Annual Interdisciplinary Geriatric Seminar, titled “Promoting partnership through protocols: intervention strategies for dementia care”, held at the Ruby Foo Hotel, Montreal. It was also presented on 2003-9-18 at Consultation-Liaison Psychiatry Rounds, Jewish General Hospital, Montreal. Download a…

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Affective disorders, sleep patterns, and treatment implications

Affective Disorders, Sleep Patterns, and Treatment Implications Problem issues in treatment of affective disorders Only 60-70% of depressed patients respond to antidepressants (in carefully done studies). The clinical reality is worse. In some patients, antidepressants worsen agitation, may increase suicidality We still don’t understand what causes depression, or how antidepressant…

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Are insomniacs sleep deprived?

Letter to the Editor of the Montreal Gazette. Every couple of weeks or so, there appears an article about sleep, most recently “A mounting sleep debt is nothing to yawn about” (Gazette 2002-12-03) Typically, the authors decry the high prevalence of insufficient sleep, the deleterious effects of sleep deprivation, the…

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Daylight saving time

Letter to the Editor of the Montreal Gazette. It appeared in the 2002-11-5 edition under the heading “Let’s make those long winter evenings brighter”. Dr. Colin Shapiro recently pointed out (Changing clocks causes temporary havoc, Gazette 2002-10-28) that the switch from Daylight Saving Time to Standard Time, on the last…

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Merger of cities

Letter to the Editor of the Montreal Gazette. It appears that the Quebec government is employing a timeworn ploy to get its way with regard to the just-introduced legislation on the forced merger of Quebec cities. The ploy is: when trying to get a deal, always ask for more than…

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Pain in brain-dead patients

Letter to the Editor of the Montreal Gazette. With reference to the article “Leading British doctors urge anesthetics for brain-dead organ donors” (Gazette, 20 Aug 2000, page A10), I find it surprising that the British Department of Health would reject in such a cavalier fashion the possibility that brain-dead individuals…

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A diet for life

What disease affects 33% of Canada’s population, and costs the health care system $6 billion per year? Obesity, spreading rapidly around the world, doubles in prevalence every five years. Clearly an epidemic. In the U.S., 1995 marked a milestone, when the prevalence of overweight in adults reached 50%. And this…

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Protocol for Management of Depressive Disorders in Cancer Patients

Protocol for Management of Depressive Disorders in Cancer Patients Diagnostic interview & instruments to identify the disorder & to identify key symptoms; include interview with family/caregivers, careful sleep assessment • Major depression • Dysthymia • Subsyndromal Depressive Disorder • Bipolar Affective Disorder, Depressed Phase • Presence of psychosis • Presence…

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Sleep, depression, fatigue, and insomnia

Sleep, Depression, Fatigue, and Insomnia Henry Olders, MD, FRCPC12 August 1998 IntroductionRecent research indicates that an important cause of depression may be sleeping too much; specifically, too much Rapid Eye Movement (REM) sleep. In those individuals without a genetic predisposition to depression, too much REM sleep can cause some depressive…

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The Y2K problem

This letter to the editor of the Montreal Gazette appeared  in an edited form in the 1998-5-30 edition with the title “”Programmers can do in millenium bug” The millenium bug has received a great deal of editorial comment. Hapless users of elevators, automobiles, banks, governments and all the other products,…

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