Do PPIs suppress B12?

This letter to the Editor was published in the November 2001 issue of Parkhurst Exchange, p7 Gentlemen: In the June 2001 issure of Parkhurst Exchange, your consultant AS reported no serious side effects from the longterm use of pantoprazole, to his knowledge. Gastric acid suppressive therapy in general has been…

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Comment on: White matter, red flag (letter to the editor, Parkhurst Exchange, sent 2010-4-12)

The Q&A response to the question “What could multiple hyperdensities on brain MRI in the absence of migraine indicate?” (Parkhurst Exchange, April 2010, p28) did not include B12 deficiency as a possible cause. There are a number of case reports (1-4) reporting the finding of white matter hyperintensities on T2-weighted…

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Comment on “Age-related macular degeneration” (letter to the editor, Parkhurst Exchange, submitted 2008-11-25)

The article “Age-related macular degeneration” Oct 2008, p52) lists the risk factors for AMD as age, genetics, history of smoking, Caucasian race, and diet low in antioxidants. Not mentioned was the association between a lower risk of AMD and higher fish and/or omega-3 fatty acid consumption. Augood C, Chakravarthy U,…

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Tasco Telescope 40-060578 / 40-060660 / 46-060525 Owner’s Manual / Manuel du propriétaire / Manual des usuario / Manuale dell’utente / Benutzerhandbuch / Handleiding / Manual do utilizador

PDF of the manual for three Tasco telescopes. [gview file=”http://henry.olders.ca/wordpress/wp-content/uploads/2015/12/Tasco-Telescope-40-060578-40-060660-46-060525-Owners-Manual-Manuel-du-propriétaire-Manual-des-usuario-Manuale-dellutente-Benutzerhandbuch-Handleiding-Manual-do-utilizador.pdf”]

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Methionine content of food items

To facilitate following a methionine restriction diet, I’ve put together a Filemaker solution which will provide you with the methionine content for the majority of the items in the USDA nutrients database, version SR27. The solution also includes the content of cysteine, leucine, glycine, and choline. The Predicted Renal Acid Load…

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Traiter les patients difficiles

English version Principes généraux relatifs aux traitements des patients difficiles dont la fonction cognitive est intacte En tant que soignant professionnel, nous devons souvent nous dévouer “corps et âme” pour nos patients.  C’est très valorisant de savoir à quel point nos patients apprécient et qu’ils nous témoignent leur reconnaissance. Toutefois,…

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Senate reform in Canada

With the Mike Duffy trial figuring prominently in the news these days, The NDP is renewing calls for abolition of the Senate. Instead of outright abolition of the “House of sober second thought” perhaps a major restructuring should be considered. Here is one suggestion: Reduce the size of the senate,…

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A disappointing symposium: McConnell Brain Imaging Centre 30th Anniversary

Yesterday I attended an all-day symposium at the Montreal Neurological Institute, to celebrate the 30th anniversary of the founding of the McConnell Brain Imaging Centre. I went to hear talks by David Van Essen, Principal Investigator, The Human Connectome Project; Henry Markram, Director, The Blue Brain Project, and Coordinator, The Human Brain Project; and Robert…

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Methionine Restriction abstracts

Grandison, R. C., M. D. Piper, and L. Partridge (2009) Nature 462:1061-1064. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Dietary restriction extends healthy lifespan in diverse organisms and reduces fecundity. It is widely assumed to induce adaptive reallocation of nutrients from reproduction to somatic maintenance, aiding…

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Research Proposal: Treating Cancer-Related Anorexia-Cachexia
 with a Methionine Restricted Diet

Henry Olders, MD November 6, 2013 Research Proposal: Treating Cancer-Related Anorexia-Cachexia with a Methionine Restricted Diet Anorexia and cachexia are frequent concomitants of the later stages of cancer, and contribute significantly to poor quality of life (QOL). Moreover, family members and friends of cancer patients with anorexia and cachexia are…

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The war against Islamic State

Western democracies are lining up to engage in bombing raids against Islamic State installations, citing the IS (aka ISIS, or ISIL) terrorists as particularly cruel and barbaric, a scourge that needs to be eliminated. We’ve seen the gruesome beheadings, and heard the warnings that Canadians may become radicalized, join IS,…

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Assisted suicide

In Canada and Quebec, the debate over the right to die with dignity, medically assisted suicide, and euthanasia is often heated. I am struck by the inconsistency, perhaps even hypocrisy, of governments that maintain that it is OK for individuals to commit suicide, but not to receive help from anyone…

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Why we get old and die, and what to do about it

This presentation was most recently given at the Westmount Healthy City Project, on 2015-10-29.  It was also presented at: Institut universitaire en santé mentale Douglas Grand Rounds, 2013-5-23 Jewish General Hospital Department of Psychiatry Clinical Grand Rounds, 2012-4-12 McGill Geriatric Medicine Grand Rounds, Montreal General Hospital, 2012-1-24 Ste. Anne’s Hospital, Continuing…

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Letter to the Editor: Comment on ‘Acute Impact of Immediate Release Methylphenidate Administered Three Times a Day on Sleep in Children with Attention-Deficit/Hyperactivity Disorder’

The study reported on in the article “Acute impact of immediate release methylphenidate administered three times a day on sleep in children with attention-deficit/hyperactivity disorder” (Corkum, Panton, Ironside, Macpherson, & Williams, 2008) found a significant reduction in total sleep time of almost an hour with medication compared to the no…

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Letter to the Editor: PPIs, B12, and falls. Comment on ‘Use of proton pump inhibitors and risk of osteoporosis-related fractures’

This letter to the editor of the “Canadian Medical Association Journal” was published electronically on the CMAJ website, on 2008-11-18, in response to this article:  Targownik LE, Lix LM, Metge CJ, Prior HJ, Leung S, Leslie WD. Use of proton pump inhibitors and risk of osteoporosis-related fractures. CMAJ. 2008;179:319-326. Article…

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Depression in Long Term Care

This presentation was given on 2008-11-17 at Ste. Anne’s Hospital in the Department of Psychiatry Conference Series, and on 2008-11-20 to the Head Nurses at Ste. Anne’s Hospital. It had previously been presented to staff of CSSS Cavendish on 2008-10-8, at Centre d’Accueil Henri-Bradet. Download a pdf of the slides and…

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How to discourage gas consumption

Letter to the Editor, submitted to the Montreal Gazette on 2008-8-28. Many companies provide parking at no charge for their employees. This represents a subsidy, as parking spaces involve considerable costs including initial construction, drainage, paving, lighting as well as ongoing expenses such as snow removal, security, and electricity. Never…

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Does a fish a day keep the doctor away? The role of omega-3 fatty acids in psychiatry

This presentation was given on 2006-9-5 at Ste. Anne’s Hospital, Ste-Anne-de-Bellevue, Québec. Earlier versions of this talk were presented at: • Consultation-Liaison Psychiatry Rounds, Sir Mortimer B. Davis – Jewish General Hospital, 2002-6-28 • Department of Psychiatry Clinical Grand Rounds, Sir Mortimer B. Davis – Jewish General Hospital, 2002-9-12 •…

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Does too much sleep cause depression?

Presented at Ste. Anne’s Hospital 2006-5-9 and on 2006-6-1. Some proverbs about sleep: “One hour’s sleep before midnight is worth two hours after.”
—John Rays (1627-1705): A Compleat Collection of English Proverbs, 1670 “Plough deep while sluggards sleep.”
—Benjamin franklin (1706-1790): Maxim prefixed to Poor Richard’s Almanac, 1757 “The early bird catches…

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Ritalin (methylphenidate)

Ritalin • -more effective than sertraline in improving cognitive function and maintaining alertness in patients with traumatic brain injury (Lee H 20 p97)• better tolerated than sertraline (ibid.)• -found effective in hypoactive delirium, apathy, depressive syndrome (Meyers BJ 148 1738)• -accelerates antidepressant response in elderly (Lavretsky H 64 1410)• -useful…

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Journal club: olfactory perception, communication, and the nose-to-brain pathway

Consultation-Liaison Rounds, 05-3-3, at the SMBD – Jewish General Hospital Article: Stockhorst, U., and R. Pietrowsky (2004) Physiol Behav 83:3-11. Olfactory perception, communication, and the nose-to-brain pathway. Abstract: The present paper’s aim is of to give an overview about the basic knowledge as well as actual topics of olfaction–with a…

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Proposed ban of trans fats

Letter to the Editor of the Montreal Gazette. One would think we had learned nothing from the U.S. experience with Prohibition, or the War on Drugs. Banning a substance such as alcohol or marijuana inevitably leads to the creation of a criminal underground which profits enormously, and supports a large…

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Sanctuary in churches

Letter to the Editor of the Montreal Gazette. Immigration Minister Judy Sgro believes that it is inappropriate for churches and other faith communities to provide sanctuary to refugee claimants who have been ordered deported after their hearings. It has been argued that churches should not usurp the role of democratically…

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Election posters up prematurely

Letter to the Editor of the Montreal Gazette. The federal liberals have made flouting the rules an art form, as demonstrated by the sponsorship scandal, Radwanski’s expense accounts, and the Shawinigate affair. Now, in Westmount, liberal incumbent Lucienne Robillard’s overeager campaign team are breaking the rules by erecting election posters…

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Why megacities?

Letter to the Editor of the Montreal Gazette. The various arguments that have been made in favour of merging smaller municipalities into megacities have been demolished, one by one, as these undemocratically created monstrosities (monstrocities?) have failed to produce promised reductions in costs. It seems that the only remaining rationale…

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School board elections

Letter to the Editor of the Montreal Gazette. The recent school board elections were noteworthy for the low voter turnout, and for the mysterious process whereby some voters who previously had been on the English school board electoral lists saw their names turn up on the lists for francophone school…

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Transit strike

Letter to the Editor of the Montreal Gazette. The strike of MTC maintenance workers is a terrible hardship for many people, but is it really necessary to limit service to a few hours daily and none on weekends? After all, it isn’t the bus drivers who are striking; it’s the…

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Assessment of depression in dementia

This was presented on 2003-9-19 at the McGill Division of Geriatric Medicine First Annual Interdisciplinary Geriatric Seminar, titled “Promoting partnership through protocols: intervention strategies for dementia care”, held at the Ruby Foo Hotel, Montreal. It was also presented on 2003-9-18 at Consultation-Liaison Psychiatry Rounds, Jewish General Hospital, Montreal. Download a…

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Average sunrise time predicts depression prevalence

Citation: Olders H. Average sunrise time predicts depression prevalence. J Psychosom Res. 2003;55:99-105. Abstract: OBJECTIVE: Folk wisdom has it that early rising is associated with being “healthy, wealthy and wise.” A physiologic explanation may be Wiegand’s “Depressiogenic Theory of Sleep,” which posits that excessive REM sleep causes depression. Sleeping late…

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Affective disorders, sleep patterns, and treatment implications

Affective Disorders, Sleep Patterns, and Treatment Implications Problem issues in treatment of affective disorders Only 60-70% of depressed patients respond to antidepressants (in carefully done studies). The clinical reality is worse. In some patients, antidepressants worsen agitation, may increase suicidality We still don’t understand what causes depression, or how antidepressant…

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Are insomniacs sleep deprived?

Letter to the Editor of the Montreal Gazette. Every couple of weeks or so, there appears an article about sleep, most recently “A mounting sleep debt is nothing to yawn about” (Gazette 2002-12-03) Typically, the authors decry the high prevalence of insufficient sleep, the deleterious effects of sleep deprivation, the…

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Merger of cities

Letter to the Editor of the Montreal Gazette. It appears that the Quebec government is employing a timeworn ploy to get its way with regard to the just-introduced legislation on the forced merger of Quebec cities. The ploy is: when trying to get a deal, always ask for more than…

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Pain in brain-dead patients

Letter to the Editor of the Montreal Gazette. With reference to the article “Leading British doctors urge anesthetics for brain-dead organ donors” (Gazette, 20 Aug 2000, page A10), I find it surprising that the British Department of Health would reject in such a cavalier fashion the possibility that brain-dead individuals…

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A diet for life

What disease affects 33% of Canada’s population, and costs the health care system $6 billion per year? Obesity, spreading rapidly around the world, doubles in prevalence every five years. Clearly an epidemic.In the U.S., 1995 marked a milestone, when the prevalence of overweight in adults reached 50%. And this even…

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Protocol for Management of Depressive Disorders in Cancer Patients

Protocol for Management of Depressive Disorders in Cancer Patients Diagnostic interview & instruments to identify the disorder & to identify key symptoms; include interview with family/caregivers, careful sleep assessment • Major depression • Dysthymia • Subsyndromal Depressive Disorder • Bipolar Affective Disorder, Depressed Phase • Presence of psychosis • Presence…

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The Paradoxical Approach

Two ideas central to treatment: 1. Focusing on observable behavioural interaction in the present 2. Deliberate intervention to alter the ongoing system All theories of psychotherapy have limitations of practice as well as conception, inherent in their own nature (although often attributed to human nature). Basic Premise: the kinds of…

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Prosody in affective disorders and schizophrenia: diagnosis using computer simulations of neural networks

Henry Olders, MD, FRCPC Douglas Hospital Verdun, Quebec, Canada 2/17/09 Introduction Effect of medication on negative symptoms An NIMH double-blind, placebo-controlled study of the effects of antipsychotic withdrawal (four weeks drug-free) followed by four weeks’ treatment with fluphenazine HCl in 19 young patients with chronic schizophrenia showed that negative (as…

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